Within the purview of this discussion, readers shall get to know all about the causes that trigger QuickBooks Payroll Error 15227, and the solutions to fix it.
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To fix QuickBooks Error Code 15227:

Update QuickBooks to the latest release.
Run QuickBooks as an administrator.
Disable Windows Defender or any third-party antivirus.
Repair Windows Registry using a reliable tool.
Use QuickBooks File Doctor to scan and fix issues.
If the error persists, seek assistance from QuickBooks support or a professional.

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Peter